diff --git a/Jenkinsfile b/Jenkinsfile
new file mode 100644
index 0000000..0418309
--- /dev/null
+++ b/Jenkinsfile
@@ -0,0 +1,36 @@
+pipeline {
+    agent any
+    stages {
+        stage("clean") {
+            steps {
+                sh 'rm -rf ./dist/*'
+            }
+        }
+        stage("install") {
+            steps {
+                sh 'mamba env update --file environment.yml'
+                sh 'echo "mamba activate bmlsa" >> ~/.bashrc'
+            }
+        }
+        stage("build") {
+            steps {
+                sh "python -m build"
+            }
+        }
+        stage("test") {
+            steps {
+                sh "pip install dist/*.whl"
+            }
+        }
+        stage("publish") {
+            when {
+                branch '**/master'
+            }
+            steps {
+                withCredentials([usernamePassword(credentialsId: 'rs-git-package-registry-ydeng', passwordVariable: 'PASS', usernameVariable: 'USER')]) {
+                    sh "python -m twine upload --repository-url https://git.reslate.systems/api/packages/${USER}/pypi -u ${USER} -p ${PASS} --non-interactive --disable-progress-bar --verbose dist/*"
+                }
+            }
+        }
+    }
+}
\ No newline at end of file
diff --git a/environment.yml b/environment.yml
new file mode 100644
index 0000000..9fcaff8
--- /dev/null
+++ b/environment.yml
@@ -0,0 +1,8 @@
+name: bmlsa
+channels:
+  - conda-forge
+dependencies:
+  - biopython=1.81
+  - build=0.7
+  - pytest=7
+  - twine=4